About Dynameomics
Dynameomics is a pioneering platform dedicated to understanding protein folding, unfolding, and native-state dynamics through large-scale molecular dynamics (MD) simulations. Proteins are essential to life, and their structural behavior determines functions in health, biotechnology, and medicine. By simulating thousands of proteins, Dynameomics provides a unique resource to study how they behave, interact, and evolve at the atomic level.
Our mission is twofold:
Dynameomics is more than a research database it is a product-oriented platform where scientists, laboratories, and pharmaceutical companies can access high-quality simulation data, protein libraries, and laboratory solutions to support both academic research and industrial applications.
Source Databases: SCOP, CATH, Dali Domain Dictionary
Purpose: Integrates fold classifications to create a comprehensive protein fold reference.
Benefit: Ensures that simulations cover the full diversity of known protein structures.
Molecular Dynamics Simulations
Feature | Description | Focus and Benefits |
Number of simulations | Thousands of high-resolution MD simulations | Explore protein folding pathways and unfolding mechanisms |
Data coverage | Includes enzymes, structural proteins, transcription factors, and binding proteins | Comprehensive protein structure analysis and native-state dynamics |
Insights provided | Folding pathways, unfolding mechanisms, native-state dynamics | Supports molecular dynamics simulations, structural biology research, and biotechnology applications |
Products and Solutions for Researchers
Reagents and Kits: High-quality molecular biology and protein research kits.
Computational Tools: Software and simulation solutions for structural biology and protein modeling.
Applications: Supports academic research, drug discovery, and biotechnology innovation.
Protein Targets and Large-Scale Simulations
At the core of Dynameomics lies the systematic study of protein folding, unfolding, and natural-state dynamics through advanced molecular dynamics simulations.
To achieve this, we selected representative protein structures from the Protein Data Bank (PDB), covering a wide spectrum of protein folds defined by SCOP, CATH, and Dali classifications.
Our simulation strategy includes:
- Over 11,000 molecular dynamics simulations, creating one of the most comprehensive protein dynamics datasets available.
- More than 2,000 unique proteins analyzed, spanning enzymes, structural proteins, transcription factors, and binding proteins.
- 340+ microseconds of aggregated simulation time, offering unmatched insights into protein behavior at the atomic level.
These large-scale simulations allow us to:
- Map folding pathways and unfolding mechanisms with high precision.
- Study proteins from a wide range of organisms, including humans, model organisms (E. coli, yeast, mouse, Drosophila), and thermophilic species.
- Provide a reference resource for biotechnology, drug design, and structural biology research
Frequently asked questions
The Dynameomics Database is a collection of large-scale molecular dynamics simulations covering thousands of proteins, fragments, and structural libraries. It provides valuable datasets for researchers in biophysics, computational biology, and drug discovery.
It is designed for researchers, students, and biotech professionals interested in protein folding, molecular modeling, and structure-based drug design.
You will find:
- Protein simulations across many fold families.
- Fragment and structural libraries.
- Side-chain rotamer libraries.
- Peptide simulations (GGXGG and others).
Access is available through the official Dynameomics portal. Simply follow the link provided on our website to explore proteins, fragments, and datasets.
Yes, most of the Dynameomics data is available for open academic research. Some tools or specialized datasets may require additional licensing.
Absolutely. The datasets are compatible with common bioinformatics, molec